DAPHNETIN-7-METHYL ETHER
Daphnetin 7-methyl ethe
CAS: 19492-03-6
Molecular Formula: C10H8O4
DAPHNETIN-7-METHYL ETHER - Names and Identifiers
DAPHNETIN-7-METHYL ETHER - Physico-chemical Properties
| Molecular Formula | C10H8O4 |
| Molar Mass | 192.17 |
| Density | 1.377 |
| Melting Point | 176°C |
| Boling Point | 381.9±42.0 °C(Predicted) |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
| Appearance | White solid |
| BRN | 168393 |
| pKa | 7.78±0.20(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD00075652 |
DAPHNETIN-7-METHYL ETHER - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
DAPHNETIN-7-METHYL ETHER - Reference Information
| application | 7-methoxy -8-hydroxycoumarin (dapenin -7-methyl ether) is extracted from green pepper (a traditional Chinese medicine, widely used in the treatment of colds, stomach pain, diarrhea and jaundice), which can significantly inhibit the HL-60 proliferation of human leukocytes, play an anti-tumor role. |
| preparation | preparation of 7-methoxy -8-hydroxycoumarin (daphenin -7-methyl ether) (ii-aa): weigh 7,8-dihydroxycoumarin 500mg into a three-mouth bottle, add N,N-dimethylformamide 5mL dissolved sample, add 850mg sodium carbonate, after fully stirring for 15min, methyl iodide is added dropwise by 560 μL, the reaction is carried out at 0 ℃, TLC monitors the reaction process, and the reaction ends after 5h. The reaction droplets are added to 100mL of ice water, hydrochloric acid is added to adjust the pH to be about 3, ethyl acetate is extracted (50mL × 3), ethyl acetate phase is combined, saturated salt is washed twice, and ethyl acetate is removed by decompression distillation of the organic phase, I .e. crude product is separated by silica gel column, the mobile phase is V petroleum ether: V dichloromethane: V acetone = 2:1:0.2. The solvent is removed by vacuum distillation and vacuum drying to obtain 260mg of white solid. |
Last Update：2024-04-09 20:49:11
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Product Name: Daphnetin 7-methyl ethe Visit Supplier Webpage Request for quotationCAS: 19492-03-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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